Acyclovir CAS:59277-89-3 CAS NO.59277-89-3

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Name: Acyclovir

Synonyms: acycloguanosine

CAS:59277-89-3

MF: C₈H₁₁N₅O₃

ITEMS	SPECIFICATIONS	RESULT
Appearance	White crystalline powder	Complies
Assay	98.0%-102.0%	99.2%
Identification	The retention time of the major peak in the chromatogram of theAssay prepration corresponds to that in the chromatogram of the standard preparation,as obtained in the assay	Complies
Specific rotation	Between -28.6°and -35.0°, measured at 20°	-32.8°
Water	NMT 0.5%	0.12%
Residue on ignition	NMT 0.2%	0.11%
Heavy metals	NMT 0.001%	Complies
Related compounds by hplc	Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5%	Fructose: 0.03% Compound A: 0.04% Total impurities: 0.07%
Particle size	90% less than 350 microns	Complies
Limit of sulfamate and sulfate	Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10%	Complies
Residual Solvent	Methylene Chloride not more than 250μg/g	Not detected
	Acetone not mor than 2500μg/g
	Isopropanol not more than 5000μg/g
	Ethanenitrile not more than 400μg/g
	n-hexane not more than 290μg/g
	Ethyl Acetate not more than 2500μg/g
	Pyridine not more than 100μg/g
Conclusion	Conform with the Standard