Irbesartan CAS NO.138402-11-6

Olmesartan medoxomil has excellent antihypertensive effect. Seven placebo-controlled clinical studies showed that olmesartan medoxomil has a potent antihypertensive effect with daily doses of 5 mg, 20 mg and 40 mg reducing the systolic blood pressure by 12.4 mmHg, 15.1 mmHg and 17.6 mmHg, respectively ; Reduced sitting diastolic blood pressure 9.8 mmHg, 12.2 mmHg and 13.1 mmHg

The antihypertensive effect of olmesartan medoxomil has no significant difference in patients of different genders and ages (<65 years or ≥65 years). The recommended initial dose of olmesartan medoxomil in the United States is 20 mg / day, with an additional 40 mg / day if necessary. The investigators looked at the antihypertensive effect of olmesartan medoxomil 20 mg qd, and ambulatory blood pressure monitoring at 24 hours showed that this dose reduced average systolic blood pressure by 15.2 mm Hg and mean diastolic blood pressure by 11.2 mm Hg, the same as olmesartan medoxomil 10 mg bid , Were significantly better than placebo. And at each observation time point of blood pressure are more significant, the degree of similar decline. Clinical observations fully confirmed, oral olmesartan medoxomil once a day for 24 hours to control blood pressure