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Zoledronic Acid CAS NO.118072-93-8
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C,D/P,T/T,Other
- Available Specifications:
99%(100-500)Gram
- Product Details
Keywords
- 118072-93-8
- ZOLEDRONATE
- CGP-4244
Quick Details
- ProName: Zoledronic Acid
- CasNo: 118072-93-8
- Molecular Formula: C5H10N2O7P2
- Appearance: White crystalline powder
- Application: Metabolism Drug; Carcino-Chemotherapeu...
- DeliveryTime: prompt shipment
- PackAge: on request
- Port: Shanghai,China
- ProductionCapacity: 2 Metric Ton/Month
- Purity: 99%min
- Storage: Stored in cool and ventilated warehous...
- Transportation: BY SEA,AIR
- LimitNum: 100 Gram
- Related Substances: not avaliable
- Residue on Ignition: not avaliable
- Heavy Metal: not avaliable
- Valid Period: 2 years
- CAS No.: 118072-93-8
Superiority
| Synonym: | Zoledronate |
| Application: | A protein kinase C activator with apoptotic effects |
| CAS Number: | 118072-93-8 |
| Purity: | ≥99% |
| Molecular Weight: | 272.09 |
| Molecular Formula: | C5H10N2O7P2 |
Description
Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM. In cultures of freshly isolated rabbit and human osteoclasts zoledronic acid (10-100 μM) induced morphological features similar to apoptosis and Osteoclastogenesis was inhibited with an IC50 of 15 nM.
Details
Technical Information
| Physical State: | Solid |
| Solubility: | Soluble in DMSO (0.004 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| Storage: | Store at -20° C |
| IC50: | Morphological features similar to apoptosis and Osteoclastogenesis: IC50 = 15 nM (cultures of freshly isolated rabbit and human osteoclasts ); Proliferation of human foetal osteoblastic cell: IC50 = 40 µM |
Safety and Reference Information
| PubChem CID: | 68740 |
| MDL Number: | MFCD00867791 |
| SMILES: | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O |