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Entecavir monohydrate CAS NO.142217-69-4
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- Available Specifications:
99.5%(5-10)Gram
- Product Details
Keywords
- 1367369-76-3
- Entecavir monohydrate
- Entecavir
Quick Details
- ProName: Entecavir monohydrate
- CasNo: 142217-69-4
- Molecular Formula: C12H15N5O3.H2O
- Appearance: White to Off-White/Yellow Crystalline ...
- Application: An oral antiviral drug used in the tre...
- DeliveryTime: prompt shipment
- PackAge: According to customer requirements
- Port: Shanghai,Qingdao,Xingang
- ProductionCapacity: 2000 Kilogram/Year
- Purity: 99.5%
- Storage: -20°C Freezer
- Transportation: BY AIR
- LimitNum: 5 Gram
- Related Substances: 99.5%
- Residue on Ignition: 0.1%
- Heavy Metal: 0
- Valid Period: 1 year
- CAS No.: 142217-69-4
- mp: 249-252°C
- MW: 277.283
- EINECS: NONE
- CAS DataBase Reference: 142217-69-4
Superiority
Chemical Name: Entecavir
Molecular Formula: C12H15N5O3
Formula Weight: 277.283
CAS No.:142217-69-4;1367369-76-3
White to Off-White/Yellow Crystalline Powder
Purity:99.5%
Single impurity:NMT0.1%
Total impurity:NMT0.3%
Adefovir dipivoxil regulates the immune system and let the immune system to attack liver cells of the intrusion of HBV , and clear the virus, but this method will develop resistance, at the same time for patients with renal dysfunction or potential renal dysfunction risk, the use of adefovir dipivoxil chronic treatment will lead to renal toxicity. If eating 1 mg every day, in the three months will produce nephrotoxicity, this will lead to severe renal failure. These patients should be closely monitoring renal function and making appropriate dosage adjustments.
Bisphosphonates is quick conversion of adefovir dipivoxil in vivo, adefovir dipivoxil is a kind of single adenosine monophosphate acyclic nucleoside analogues, became to activity of the metabolites of adefovir in cellular kinases by phosphorylation in cellular kinases. A Duff Vee two phosphate through the following two ways to suppress HBV DNA polymerase (reverse transcriptase); one is with the natural substrate of deoxyadenosine triphosphate competition, the second is the integration of viral DNA and induce DNA chain elongation terminated. A Duff Vee two phosphate to HBV DNA polymerase inhibition constant (KI) is 0.1μM, but of human DNA polymeraseα and γ is weak and Ki values were 1.18μM and 0.97 μM.
Anti-viral activity: in the human hepatoma cell line transfected with HBV, the concentration of A Duff Vee inhibited 50% viral DNA replication (IC50) is from 0.2 to 2.5uM.
Adefovir dipivoxil applies for the treatment of hepatitis B virus replication activity and serum amino acid transfer enzyme and persistently elevated liver decompensation adult patients with chronic hepatitis B patients.
Liver injury is often encountered in the course of hepatitis B treatment, hepatitis B therapy is inappropriate, as well as long-term use of drugs on the liver damage, will lead to the occurrence of liver damage.
After long-term taking adefovir dipivoxil tablets, once the withdrawal will aggravate the damage of liver function. Therefore, for stopping taking the patients should be monitored for liver function.
Adefovir dipivoxil is more moderate suitable for long-term use, suitable for patients with lamivudine resistant patients, their chances of producing drug resistance is small, because the amount is less, side effects are small.
Entecavir is new, antiviral effect is also strong, if not treated with lamivudine, the possible resistance is the smallest, but it and lamivudine have cross resistance, if treated with lamivudine to take entecavir produced resistance rate is much greater.
The above information is Chemicalbook Hanya edited.
Details
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Name |
Entecavir(monohydrate) |
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Batch No. |
20120303 |
Quantity |
500kg |
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Date of Production |
Mar.3rd,2012 |
Analysis Date |
Mar.4th,2012 |
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Product standard |
Enterprise standard |
Expiry Date |
Mar.2nd,2014 |
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Item |
Requirements |
Test Results |
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Description |
White crystalline powder |
White crystalline powder |
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Identification |
The IR absorption spectrum of the sample must be concordant with entecavir |
conform |
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Optical rotation |
+24.0°—+28.0°(MeOH:DMF=1:1 1%) |
+26.3° |
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Water |
5.8%—6.5% |
6.25% |
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Residue on ignition |
0.2%(max) |
0.06% |
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Total impurities |
0.3%(max) |
0.06% |
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Single impurity |
0.1%(max) |
0.03% |
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Assay(HPLC) |
99.0%(min) |
99.9% |
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Application:An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.
142217-69-4;1367369-76-3 entecavir
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