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Fluocinonide 356-12-7 CAS NO.356-12-7
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 100 Pound
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
99%(100-500)Metric Ton
- Product Details
Keywords
- 356-12-7
- 21-acetate;flucinar
- Topsymin
Quick Details
- ProName: Fluocinonide 356-12-7
- CasNo: 356-12-7
- Molecular Formula: C26H32F2O7
- Appearance: white crystalline powder
- Application: For external use only applies to gluco...
- DeliveryTime: 7 days
- PackAge: 1,5,25kg
- Port: Shanghai
- ProductionCapacity: 20 Metric Ton/Year
- Purity: 99.0%
- Storage: stores in a well-ventilated, cool, dry...
- Transportation: by sea,air
- LimitNum: 100 Pound
- Moisture Content: 0.1%
- Impurity: 0.01%
- CAS#: 356-12-7
Superiority
The Fluocinolide with CAS registry number of 356-12-7 is also known as Topsymin. The systematic name is 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox oethyl acetate. It belongs to product categories of Steroids. Its EINECS registry number is 206-597-6 . In addition, the formula is C26H32F2O7 and the molecular weight is 494.52. This chemical is a white crystalline powder and used for atopic dermatitis, eczema and so on.
Physical properties about Fluocinolide are:
(1)ACD/LogP: 3.36;
(2)# of Rule of 5 Violations: 0;
(3)ACD/LogD (pH 5.5): 3.36;
(4)ACD/LogD (pH 7.4): 3.36;
(5)ACD/BCF (pH 5.5): 209.69;
(6)ACD/BCF (pH 7.4): 209.69;
(7)ACD/KOC (pH 5.5): 1597.31;
(8)ACD/KOC (pH 7.4): 1597.3;
(9)#H bond acceptors: 7;
(10)#H bond donors: 1;
(11)#Freely Rotating Bonds: 5;
(12)Index of Refraction: 1.56;
(13)Molar Refractivity: 119.09 cm3;
(14)Molar Volume: 368 cm3;
(15)Surface Tension: 49.9 dyne/cm;
(16)Density: 1.34 g/cm3;
(17)Flash Point: 311.3 °C;
(18)Enthalpy of Vaporization: 101.2 kJ/mol;
(19)Boiling Point: 591.1 °C at 760 mmHg;
(20)Vapour Pressure: 1.97E-16 mmHg at 25 °C.
Preparation of Fluocinolide: it is prepared by reaction of acetic acid anhydride with fluocinolon-acetonid. The reaction needs reagent trimethylsilyl trifluoromethanesulfonate and solvent CH2Cl2 at the temperature of 20 °C for 5 minutes. The yield is about 100%.