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Home > Products >  Dexamethasone 50-02-2

Dexamethasone 50-02-2 CAS NO.50-02-2

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 100 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
  • Available Specifications:

    99%(100-500)Gram

  • Product Details

Keywords

  • 50-02-2
  • Dexamethasone
  • Dexamethasone 99%

Quick Details

  • ProName: Dexamethasone 50-02-2
  • CasNo: 50-02-2
  • Molecular Formula: C22H29FO5
  • Appearance: white crystalline powder
  • Application: antiinflammatory glucocorticoid
  • DeliveryTime: 7 days
  • PackAge: 1,5,25kg
  • Port: Shanghai
  • ProductionCapacity: 30 Metric Ton/Year
  • Purity: 99.0%
  • Storage: stores in a well-ventilated, cool, dry...
  • Transportation: BY SEA,AIR
  • LimitNum: 100 Gram
  • Moisture Content: 0.1%
  • Impurity: 0.01%
  • CAS No.: 50-02-2

Superiority

Synonyms: 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
Molecular Formula: C22H29FO5 
Molecular Weight: 392.46 
CAS: 50-02-2 
EINECS: 200-003-9 
Melting point: 255-264 ºC 
alpha: 75 º (c=1, dioxane) 
Water solubility: 10 mg/100 mL (25 ºC)
Appearance:white crystal power 

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant.

 

Items

Specifications

Results

Appearance

Almost white crystal or crystalline powder 

White powder, 

Identification

Infared Absorption

Complies

The retention time of the major peak  

 in the chromatogram of the 

Assay prepration corresponds to that in

 the  chromatogram of the standard preparation,

 as obtained in the assay

complies

Specific rotation

Between -28.6°and -35.0°, measured at   20°

-32.8°

Water

not more than 0.5%

0.12%

residue on ignition

not more than 0.2%

0.11%

Heavy metals

not more than 0.001%

complies

related compounds by HPLC(Test1)

Fructose not more than 0.3% Compound   

A not more than 0.3% Other individual  impurity not more than   0.1%                         

 Total   impurities not more than   0.5%                       

Fructose:   0.03%            Compound   A: 0.04%              

 Total   impurities: 0.07%

Particle size

90% less than 350 microns

complies

Limit of sulfamate and sulfate

Sulfamate ion not more than 0.10%  

  Sulfate ion not more than 0.10%

complies

Residual Solvent

Methylene Chloride not more than   250μg/g

not detected

Acetone not mor than 2500μg/g

Isopropanol not more than 5000μg/g

Ethanenitrile not more than 400μg/g

n-hexane not more than 290μg/g

Ethyl Acetate not more than 2500μg/g

Pyridine not more than 100μg/g

Assay

Topiramate contains not less than   98.0% and 

 not more than the equivalent  of 102.0% of C12H21NO8S, calculated   with  reference to the Anhydrous Basis

99.80%

Conclustion

The material complies with respect to   USP32

 

Details

Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin).  It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity,  inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce  apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.

Package

0.5kgs/Al-foil bag

1.0kgs/Al-foil bag

2.0kgs/Al-foil bag

5.0 kgs/Al-foil bag

 25.0 kgs/drum

 

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