Dexamethasone 50-02-2 CAS NO.50-02-2
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
99%(100-500)Gram
- Product Details
Keywords
- 50-02-2
- Dexamethasone
- Dexamethasone 99%
Quick Details
- ProName: Dexamethasone 50-02-2
- CasNo: 50-02-2
- Molecular Formula: C22H29FO5
- Appearance: white crystalline powder
- Application: antiinflammatory glucocorticoid
- DeliveryTime: 7 days
- PackAge: 1,5,25kg
- Port: Shanghai
- ProductionCapacity: 30 Metric Ton/Year
- Purity: 99.0%
- Storage: stores in a well-ventilated, cool, dry...
- Transportation: BY SEA,AIR
- LimitNum: 100 Gram
- Moisture Content: 0.1%
- Impurity: 0.01%
- CAS No.: 50-02-2
Superiority
Synonyms: 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
Molecular Formula: C22H29FO5
Molecular Weight: 392.46
CAS: 50-02-2
EINECS: 200-003-9
Melting point: 255-264 ºC
alpha: 75 º (c=1, dioxane)
Water solubility: 10 mg/100 mL (25 ºC)
Appearance:white crystal power
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant.
Items |
Specifications |
Results |
Appearance |
Almost white crystal or crystalline powder |
White powder, |
Identification |
Infared Absorption |
Complies |
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay |
complies |
|
Specific rotation |
Between -28.6°and -35.0°, measured at 20° |
-32.8° |
Water |
not more than 0.5% |
0.12% |
residue on ignition |
not more than 0.2% |
0.11% |
Heavy metals |
not more than 0.001% |
complies |
related compounds by HPLC(Test1) |
Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% |
Fructose: 0.03% Compound A: 0.04% Total impurities: 0.07% |
Particle size |
90% less than 350 microns |
complies |
Limit of sulfamate and sulfate |
Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% |
complies |
Residual Solvent |
Methylene Chloride not more than 250μg/g |
not detected |
Acetone not mor than 2500μg/g |
||
Isopropanol not more than 5000μg/g |
||
Ethanenitrile not more than 400μg/g |
||
n-hexane not more than 290μg/g |
||
Ethyl Acetate not more than 2500μg/g |
||
Pyridine not more than 100μg/g |
||
Assay |
Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis |
99.80% |
Conclustion |
The material complies with respect to USP32 |
Details
Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.
Package
0.5kgs/Al-foil bag
1.0kgs/Al-foil bag
2.0kgs/Al-foil bag
5.0 kgs/Al-foil bag
25.0 kgs/drum