China (Mainland)
Premiumsupplier 
Prednisolone Acetate EP6 CAS NO.52-21-1
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 10 Gram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
99%(100-500)Gram
- Product Details
Keywords
- 52-21-1
- Prednisolone-21-acetate
- Prednisolone Acetate
Quick Details
- ProName: Prednisolone Acetate EP6
- CasNo: 52-21-1
- Molecular Formula: C23H30O6
- Appearance: white crystalline powder
- Application: Synthetic corticosteroid; metabolicall...
- DeliveryTime: 7 days
- PackAge: 1,5,25kg
- Port: Shanghai
- ProductionCapacity: 3 Metric Ton/Month
- Purity: 99.0%
- Storage: RT
- Transportation: By sea, air
- LimitNum: 10 Gram
- Moisture Content: 0.1%
- Impurity: 0.01%
- CAS: 52-21-1
Superiority
Prednisolone Acetate
Prednisolone is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. It is the active metabolite of the drugprednisone and is used especially in patients with hepatic failure, as these individuals are unable to metabolise prednisone into prednisolone.
Details
Mechanism of action
Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. AlphaGR and BetaGR are found in virtually all tissues with variable numbers between 3000 and 10000 per cell, depending on the tissue involved. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others.
Not all metabolic actions on genes are known. Most mediator proteins are enzymes, e.g., cAMP-dependent kinase
Anti-inflammatory and immunosuppressive actions:
- Inhibition of gene transcription for COX-2, cytokines, cell adhesion molecules, and inducible NO synthase
- Blockage of Vit D3-mediated induction of osteocalcin gene in osteoblasts
- Modification of collegenase gene transcription
- Increase synthesis annexin-1, important in negative feedback on hypothalamus and anterior pituitary gland
Regulation of gene suppression leads to systemic suppression of inflammation and immune response. This is of clinical usefulness but ultimately leads to gluconeogenesis, proteolysis and lipolysis. Gene transcription returns to normal after cessation, but sudden stoppage can cause Addison's disease. Osteoporosis is permanent.
Adverse effects
Possible side-effects include fluid retention of the face (moon face, Cushing's syndrome), acne,constipation, and mood swings.
A lengthy course of prednisolone can cause bloody or black tarry stools from bleeding into the stomach (this requires urgent medical attention); filling or rounding out of the face; muscle cramps or pain; muscle weakness; nausea; pain in back, hips, ribs, arms, shoulders, or legs; reddish-purple stretch marks on arms, face, legs, trunk, or groin; thin and shiny skin; unusual bruising; urinating at night; rapid weight gain; and wounds that will not heal.
Prolonged use of prednisolone can lead to the development of osteoporosis which makes bones more fragile and susceptible to fractures. One way to help alleviate this side effect is through the use of calcium and vitamin D supplements.
Swelling of the pancreas has also been reported.
Prednisolone can cause increased blood sugar levels for diabetics.
Other effects include decreased or blurred vision, increased eye pressure, increased thirst, cataract formation, confusion, rare cases of dementiain otherwise-healthy elderly patients, and nervousness.
Loteprednol is an analog drug that has reduced adverse ocular effects.