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Sirolimus CAS NO.53123-88-9
- FOB Price: USD: 1.00-1.00 /Kilogram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
99%(1-500)Kilogram
- Product Details
Keywords
- 53123-88-9
- Rapammune
- Rapamycin
Quick Details
- ProName: Sirolimus
- CasNo: 53123-88-9
- Molecular Formula: C51H79NO13
- Appearance: off-white or yellow crystalline powder
- Application: Metabolism Drug; Immuno-suppressant
- DeliveryTime: prompt shipment
- PackAge: on request
- Port: Shanghai,China
- ProductionCapacity: 100 Kilogram/Day
- Purity: 99%min
- Storage: RT.
- Transportation: by sea,air
- LimitNum: 100 Gram
- Related Substances: ≤0.2%
- Residue on Ignition: 0.1%
- Heavy Metal: ≤10ppm
- Valid Period: 2 years
- CAS No.: 53123-88-9
Superiority
Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating. Sirolimus works, in part, by eliminating old and abnormal white blood cells.[citation needed] Sirolimus is effective in mice with autoimmunity and in children with a rare condition called autoimmune lymphoproliferative syndrome (ALPS).
Details
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Item |
Specification |
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Appearance |
Odorless,off-white or yellow crystalline powder |
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Identification A |
The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard |
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Identification B |
The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm,277nm,288nm as that of a similar preparation of in-house reference standard |
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Identification C |
The retention time of the peaks for the Trans-and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the Assay |
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Loss on drying |
≤ 0.5% |
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Heavy metals |
≤ 0.002% |
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Chromatographic purity |
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Individual impurity |
≤ 1.0% |
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Total impurities |
≤ 2.0% |
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Cis-stereoisomer of sirolimus |
≤ 5.0% |
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Assay |
98.0-102.0% calculated trans-and cis-stereoisomers of sirolimus on the dried basis |
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Residual organic solvents |
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Ethanol |
≤ 5000ppm |
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Ethyl acetate |
≤ 5000ppm |
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Acetone |
≤ 5000ppm |
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